GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7112513 | 1 | rs473188 | chr11:116812029 | PCSK7 | chr11:117075789-117102811:- | -0.38 | -4.86 | 1.74E-6 | Protein quantitative trait loci |
| BLCA | cis | rs477692 | 1 | rs473771 | chr10:131408155 | MGMT | chr10:131265454-131565783:+ | 0.21 | 4.49 | 9.37E-6 | Response to temozolomide |
| BLCA | cis | rs12220238 | 1 | rs4745740 | chr10:75942469 | ADK | chr10:75910965-76469059:+ | 0.28 | 4.41 | 1.34E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs477692 | 1 | rs4750759 | chr10:131436603 | MGMT | chr10:131265454-131565783:+ | -0.22 | -4.83 | 1.93E-6 | Response to temozolomide |
| BLCA | cis | rs7927771 | 1 | rs4752797 | chr11:47874364 | C1QTNF4 | chr11:47611216-47615961:- | -0.29 | -5.34 | 1.61E-7 | Subjective well-being |
| BLCA | cis | rs7927771 | 1 | rs4752856 | chr11:47648042 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.84 | 1.14E-8 | Subjective well-being |
| BLCA | cis | rs7927771 | 1 | rs4752857 | chr11:47655752 | C1QTNF4 | chr11:47611216-47615961:- | -0.29 | -5.62 | 3.62E-8 | Subjective well-being |
| BLCA | cis | rs7927771 | 1 | rs4752873 | chr11:47857520 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.58 | 4.52E-8 | Subjective well-being |
| BLCA | cis | rs4237643 | 1 | rs4755726 | chr11:43642130 | HSD17B12 | chr11:43702143-43878160:+ | -0.42 | -7.01 | 1.1E-11 | Forced vital capacity |
| BLCA | cis | rs4759042 | 1 | rs4759042 | chr12:57377347 | PRIM1 | chr12:57125370-57146146:- | 0.16 | 3.94 | 9.62E-5 | Migraine |
| BLCA | cis | rs877636 | 1 | rs4759229 | chr12:56474480 | RPS26 | chr12:56435686-56438005:+ | -0.47 | -7.92 | 2.6E-14 | Cognitive function |
| BLCA | cis | rs4763879 | 1 | rs4763879 | chr12:9910164 | CLECL1 | chr12:9868457-9885860:- | -0.21 | -5.21 | 3.11E-7 | Type 1 diabetes |
| BLCA | cis | rs4764124 | 1 | rs4764124 | chr12:14966604 | C12orf60 | chr12:14956506-14976789:+ | -0.32 | -4.89 | 1.47E-6 | Pubertal anthropometrics |
| BLCA | cis | rs4766646 | 1 | rs4766646 | chr12:110398145 | TRPV4 | chr12:110220894-110271212:- | -0.26 | -4.08 | 5.52E-5 | Metabolite levels (MHPG) |
| BLCA | cis | rs4776059 | 1 | rs4776058 | chr15:52880263 | ARPP19 | chr15:52839432-52861364:- | 0.22 | 4.06 | 5.93E-5 | Schizophrenia |